Analytical services

Unsurpassed sensitivity of neurochemical HPLC methods
- Dopamine, noradrenaline, adrenaline
- Serotonin
- Acetylcholine
- Histamine
- Glutamate, Aspartate, GABA

The experimental armamentarium of Pronexus covers the techniques for analysis of all classic neurotransmitters, neuromodulators, nutrients, metabolites and other neurochemically active molecules identified as the surrogate markers of neurological and psychiatric disorders.

		Ultra-sensitive detection of monoamines Unique fluorescence derivatization/HPLC methods developed for simultaneous determination of noradrenaline, dopamine and serotonin down to 10 -11 M [100 atmol/20 µl]  and for histamine [300 atmol/20 µl]
		HPLC techniques optimized for determination of neurotransmitters, neuromodulators and related molecules in the microdialysates  Serotonin, noradrenaline, dopamine and their metabolites, acetylcholine, GABA, aspartate and glutamate, glycine, physiological amino acids, histamine, adenosine and other purines, cAMP, cGMP, kynurenic acid, radical oxygen species (ROS), NO2-/NO3-, Mg2+, Ca2+and other ions
		HPLC and LC/MS methods for analysis of biological samples Determination of neurotransmitters or specified biomolecules, drug levels in plasma, CSF and tissue extracts
		HPLC and enzymatic spectrophotometric assays for clinical microdialysates Amino acid analysis, lactate, pyruvate, glycerol, glucose, enzymes and clinical biomarkers