Technology benefits
|
Microdialysis and biosensor techniques allow measuring the release, uptake and metabolism of neurotransmitters and other neuroactive molecules diffusing in the extracellular space of the brain. |
|
|
|
Studies including PK/PD and targeted bioavailability such as penetration of a drug through the blood-brain barrier could be carried-out in an elegant way by use of multiple microdialysis probes sampling from various body compartments. |
|
|
|
Microdialysis offers the closest correlation of neurochemistry in vivo to behaviour or to electrophysiological measures of brain activity. |
|
|
|
Microdialysis strengthens the predictive validity of animal models of psychiatric and neurological/neurodegenerative diseases and serves as a unique tool for investigating the mechanisms of drug actions. |
|
|
|
Microdialysis data may play a crucial role in the decision process concerning further development of a new drug. |