May 27,2010 Lyon, France. In vivo Neurochemistry Symposium
Dr. Jan Kehr, CEO of Pronexus Analytical and the senior scientist at Karolinska Institutet, Stockholm, Sweden is invited to the Sympoisium on In vivo Neurochemistry to be held in Lyon on May 27 and give a lecture entitled: “Monitoring brain neurotransmission and metabolism by in vivo microdialysis: A historical overview and future perspectives”. Dr. Kehr will be available for further discussions on preclinical contract research and collaborative project opportunities during the conference or at his e-mail: jk@pronexus.se. For information on the conference, please contact Dr. Luc Denoroy at luc.denoroy@recherche.univ-lyon 1.fr
October 30, 2009, Stockholm. Pronexus Analytical exhibited at the Society for Neuroscience 39th Annual Meeting in Chicago, IL, USA, Oct 17-21, 2009, booth #1714
Thank you for stopping by at the Pronexus booth and discussing the implications of techniques and services offered by Pronexus for your particular projects and research interests. Pronexus main focus is currently given to the development and applications of protocols and methods enabling fast in vivo neurochemicasl screening for evaluation of lead compounds and candidate drugs in experimental disease models. In addition, Pronexus together with its partner Quanteon LLC exhibited the instruments and devices for in vivo biosensor monitoring. This unique technology allows second-by-second recordings of extracellular levels of glutamate, acetylcholine, dopamine and other neuroactive molecules in the brains of awake or anaesthetized animals, as well as in brain slices.
Pronexus together with colleagues from Karolinska Institutet presented a poster (#729.12) entitled: The selective 5-HT1A receptor antagonist NAD-299 increases acetylcholine but not glutamate levels in the frontal cortex and hippocampus of awake rat. (Poster session 729, Alzheimer´s disease: Animal Models and Therapeutic Intervention, South Hall A, Wednesday, October 21, 2009, 8:00 AM-12.00 PM).
July 1, 2009, Stockholm-Bromma Pronexus moves to new laboratories
Pronexus Analytical is proud to announce that from July 1st, the company has moved to a new facility in Bromma, west Stockholm. The company´s total area of 220 sqm includes the GLP-compliant bioanalytical laboratory and the animal research facility with full regulatory approvals. Pronexus is privately owned and independent SME, yet in close association and proximity to Karolinska Institutet. Furher, Pronexus in the only small enterprise among the life science companies in the Stockholm region, which is offering experiemntal services on CNS disease models. We invite proposals on partnership formations, collaborative studies, as well as on sub-contracting opportunities both with the industry and academic institutions.
April 1, 2009, Stockholm Kent Jardemark, PhD, assoc. prof., joins Pronexus
Pronexus Analytical is expanding its range of services in preclinical neuropharmacology by introducing the electrophysiological techniques to its suite of in vivo monitoring methods. From April 1st, Dr. Kent Jardemark has joined the Pronexus team. Dr. Jardemark comes from the Department of Physiology and Pharmacology, Karolinska Institutet where he holds a position of associate professor in neuropsychopharmacology. Kent has more than 20 years of experience with electrophysiological recordings of brain activity, particularly in research focused on studying the effects of antipsychotic drugs and drugs of abuse.
February 5, 2009, Karolinska Institutet, Stockholm Scanbur Seminar
Jan Kehr presented a lecture entitled "Monitoring neurotransmitters by microdialysis and biosensors in awake rats and mice".
August 10-14, 2008, Vancouver, BC, Canada Monitoring Molecules in Neuroscience. 12th International Conference on In Vivo Methods
The 12th conference on In vivo methods was strongly represented by the contributions demonstrating the feasibility of biosensor technology for monitoring basal and stimulated neurotransmitter release and reuptake. The group of Prof. Gerhardt at University of Kentucky and the group of Dr. Kehr at Karolinska Institutet, Stockholm presented together 17 posters. In addition, there were several oral presentations and plenary lectures given by the leaders in the field of in vivo voltammetry.
Some of the major achievements are summarized below:
Glutamate biosensor
Sensors cause a minimal damage to the brain tissue, which enables to use them for repeated monitoring over several days Basal Glu levels are TTX-sensitive and calcium dependent
There are age-dependent differences in Glu basal levels, stimulated release and reuptake in various rat brain regions
Glu levels can be monitored for up to seven days in the striatum or PFC of awake mice
Cortical Glu levels are increased in pain (formalin model) and are reduced after gabapentin
mGluR2/3 agonist LY379268 attenuated potassium-induced Glu release in the rat PFC
Increase in Glu levels was monitored in the rat striatum up to 48 h after the traumatic brain injury
Acetylcholine biosensor
Recombinant human acetylcholinesterase improved the sensitivity of the ACh /Ch biosensor
Dopamine biosensor
Amperometric biosensor coated withm-phenylenediamine (mPD) was specific and sensitive to detect basal and amphetamione-stimulated DA levels in the rat striatum.
Nov 12-14th, 2007 Minneapolis, Minnesota, USA
Frontiers in Proteomics and Nanomedicine
Dr. Jan Kehr, one of the organizers of the symposium arranged by University of Minnesota, Mayo Clinic and Karolinska Institutet presented a lecture entitled "Nanomaterials for In Vivo Monitoring and Imaging", focusing on applications of microsystems and nanomaterials for microdialysis, biosensors and MRI techniques in experimental neuropharmacology.
Oct 6-7th, 2007 Seoul, Korea
3rd Symposium on Acupuncture & Meridian Studies
Dr. Jan Kehr, was invited to participate at the 3rd Symposium on Acupuncture & Meridian Studies, organized by the Society for Meridian & Acupoint, Korean Pharmacopuncture Institute and Acupuncture & Meridian Science Research Center, Seoul, Korea. The title of Dr. Kehr´s lecture was " Use of microdialysis for monitoring chemical signals in vivo: Implications in acupuncture research".
Sept 19-21, 2007 Cambridge, UK
The 4th International Conference on Clinical Microdialysis
Dr. Jan Kehr, CEO of Pronexus Analytical and the senior scientist at Karolinska Institute was invited to participate at the International Conference on Clinical Microdialysis and give two oral presentations entitled:
"Analytical techniques for Microdialysis samples" at the first conference session on Advances in Clinical Microdialysis. The second lecture
"Methodological considerations when designing and using microdialysis catheters for drug recovery" was presented in the session Monitoring drugs and drug distribution.
For information on the conference proceedings contact Mrs. Ulla Ungerstedt (ulla.ungerstedt@microdialysis,se) at CMA Microdialysis, Stockholm.
May 30 - June 2, 2007 Göteborg, Sweden
Dopamine 50 years
This symposium was organized in honour to Prof. Arvid Carlsson for his discovery of neurotransmitter dopamine in 1957. For this discovery, Prof. Carlsson won the Nobel price in medicine in 2000. Dr. Jan Kehr from the Department of physiology and pharmacology, Karolinska Institutet, Stockholm and Dr. Pia Weikop from NeuroSearch A/S, Ballerup, Denmark presented a poster entitled: "Triple-acting monoamine reuptake inhibitors: Role of dopamine in augmentation strategies for antidepressant drugs". This presentation summarized the results of the
Dr. Weikop´s thesis and the related papers recently published by these authors.
Aug 29 - Sept 2, 2006, Helsinki, Finland
International Congress and 54th Annual Meeting of the Society for Medicinal Plant Research
Dr. Jan Kehr from Pronexus Analytical was invited to present the results of the studies "Effects of acute and repeated administration of Hypericum perforatum extract (WS 5572®) and its main constituents on extracellular levels of serotonin, noradrenaline and dopamine in the rat brain: A microdialysis study" (oral presentation) and " Effects of chronic administration of Ginkgo biloba extract (EGb 761®) on levels of dopamine, noradrenaline and serotonin in the prefrontal cortex of the awake rat" (poster). Both studies were sponsored by Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany.
May 19-22, 2006 Villasimius, Sardinia, Italy
Monitoring Molecules in Neuroscience. 11th International Conference on In Vivo Methods
Dr. J. Kehr and Dr. D. Scheller from Schwarz Biosciences, Monheim, Germany presented a poster entitled "Evidence for Continuous Dopamine Receptor Stimulation by Rotigotine in Freely Moving Rats". Rotigotine is a non-ergolinic dopamine agonist, which was developed as a patch for therapy of Parkinson’s disease. The study was designed to evaluate whether the continuous administration of rotigotine mediates a continuous stimulation of dopamine receptors.
April 27, 2006 Suwon, Korea
International Symposium on Advanced Nanodevices Technology
At the occasion of the inauguration of Korea Advanced Nano Fab Center (KANC), Dr. Kehr was an invited speaker with a lecture entitled
"Nanotechnology in drug discovery: focus on in vivo monitoring and imaging techniques". The lecture gave an overview on the state-of-the-art in the field of imaging and monitoring techniques with focus on applications in neuroscience and neuropharmacology.
Dec 19th, 2005 Stockholm Sweden
CMA Microdialysis and Pronexus Analytical form strategic partnership to offer Microdialysis contract research services
Pronexus Analytical AB is a contract research organization offering services to pharmaceutical companies and research institutions active within the therapeutic area of diseases affecting the central nervous system. CMA Microdialysis AB is the leader in the development, manufacturing and marketing of Microdialysis products for scientific research and clinical diagnostics.
Through the partnership, CMA and Pronexus can enable in vivo Microdialysis and allied analytical techniques to accelerate the process of drug discovery, particularly in its late phase strengthening the functional validation of candidate drugs.
“By combining high-quality products, excellent competencies and very strong analytical skills, the partnership offers unique outsourced services to the drug industry which is requiring faster and more cost-effective throughput,” said Philip Siberg, CEO of CMA Microdialysis AB.
According to Jan Kehr, CEO of Pronexus Analytical AB: “Microdialysis is a key technology that provides the closest correlation of in vivo neurochemical data to behavioural or electrophysiological measures of brain activity. Microdialysis data can play a crucial role in decision process concerning the preclinical and clinical development phases of new drugs”.
For more information contact:
Bodil Käller, Sales & Marketing Manager Preclinical Products CMA Sweden
Tel: +46 8 470 1070 bodil.kaller@microdialysis.se
Kathleen Gariepy, Product & Marketing Manager CMA USA
Tel: +1 800 440 4980 kathleen.gariepy@microdialysis.com
Jan Kehr, PhD, CEO Pronexus Analytical
Tel: +46 70 796 2606 jk@pronexus.se
About Pronexus Analytical:
Pronexus Analytical AB is a newly established spin-off company from the Karolinska Institutet and linked to the Karolinska Science Park in Stockholm. The staff scientists at Pronexus Analytical possess a unique combination of expertise and skills in Microdialysis, microsurgery and in vivo handling protocols for small rodents, neurochemical analysis, especially in high-sensitive HPLC techniques for determination of neurotransmitters, as well as, knowledge in neuroanatomy and neuropharmacology of major transmitter systems. Pronexus has all the required ethical and regulatory approvals for small animal research and is based in Sollentuna, Sweden.
About CMA Microdialysis:
CMA was formed in 1984 and was the first company in the world to market Microdialysis products and know-how. Consumables, instruments and software are sold to universities, hospitals and pharmaceutical companies as unique tools for in vivo sampling of organs and tissues. CMA has its HQ in Sweden with subsidiaries in Germany and USA.
Oct 1-4, 2005, Ischia, Italy
National Congress of the Italian Society for Neuroscience and Joint Italian-Swedish Neuroscience Meeting
Jan Kehr was an invited speaker at this joined Italian-Swedish neuroscience conference. In his presentation "Advances in analytical techniques for microdialysis", Dr. Kehr provided a summary on recent development of high sensitive derivatization techniques for HPLC determination of classical neurotransmitters in the microdialysates, plasma and other body fluids or tissue extracts.
June 24-27, 2003 Karolinska Institutet, Stockholm, Sweden
Monitoring Molecules in Neuroscience. The 10th International Conference on In Vivo Methods
Dedicated to memory of Prof. Ralph N. Adams
Dr. Jan Kehr with his colleagues at Karolinska Intitutet organized The 10th International Conference on In Vivo Methods. Pronexus Analytical AB together with Quanteon LLC, presented the Fast Analytical Sensor Technology (FAST), particularly the new FAST 16-mkI amplifier unit and the multi-site microelectrodes for rapid monitoring of glutamate release. The Proceedings book was edited by Jan Kehr, Kjell Fuxe, Urban Ungerstedt and Torgny H. Svensson.
For further information on the Proceeding book, contact Jan Kehr (jk@pronexus.se).