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Technology benefits

  Microdialysis and biosensor techniques allow measuring the release, uptake and metabolism of neurotransmitters and other neuroactive molecules diffusing in the extracellular space of the brain.
Studies including PK/PD and targeted bioavailability such as penetration of a drug through the blood-brain barrier could be carried-out in an elegant way by use of multiple microdialysis probes sampling from various body compartments.
Microdialysis offers the closest correlation of neurochemistry in vivo to behaviour or to electrophysiological measures of brain activity.
Microdialysis strengthens the predictive validity of animal models of psychiatric and neurological/neurodegenerative diseases and serves as a unique tool for investigating the mechanisms of drug actions.
Microdialysis data may play a crucial role in the decision process concerning further development of a new drug.